Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29599592 | 0.90 | YTHDC1 (0.42) | YTHDC1CYP2C19 | |
| SCHEMBL18050629 | 0.90 | YTHDC1 (0.42) | YTHDC1CYP2C19 | |
| SCHEMBL22411531 | 0.83 | YTHDC1 (0.46) | YTHDC1CCNT1CDK9CYP2C19 | |
| SCHEMBL19003136 | 0.83 | YTHDC1 (0.39) | YTHDC1 | |
| SCHEMBL5438946 | 0.83 | YTHDC1 (0.46) | YTHDC1CCNT1CDK9 | |
| SCHEMBL5435060 | 0.81 | YTHDC1 (0.44) | YTHDC1CYP2C19 | |
| SCHEMBL9936929 | 0.78 | YTHDC1 (0.42) | YTHDC1CYP2C19 | |
| SCHEMBL18050675 | 0.78 | YTHDC1 (0.41) | YTHDC1CYP2C19 | |
| SCHEMBL18050620 | 0.76 | YTHDC1 (0.40) | YTHDC1 | |
| SCHEMBL18050624 | 0.75 | YTHDC1 (0.38) | YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651951-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082997-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA-ROCHE AG (CH) | 2012-06-21 | — | — | WO | disclosed |