Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | PRF1 | P14222 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003456 | 0.87 | MAPT (0.48) | MAOBMAOAMAPTTP53DHODH | |
| SCHEMBL19003314 | 0.85 | MAOB (0.53) | MAOBMAOAHPGDSESRRGMAPT | |
| SCHEMBL19003281 | 0.81 | KDR (0.56) | MAPTTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19003280 | 0.80 | MAPT (0.52) | MAOBMAOAMAPTTP53DHODH | |
| SCHEMBL18985206 | 0.78 | TP53 (0.67) | MAPTTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18985289 | 0.75 | MAOB (0.64) | MAOBMAOAESRRGMAPTTP53 | |
| SCHEMBL19003464 | 0.73 | EGFR (0.53) | MAPTTP53DHODHSMN1; SMN2MEN1 | |
| SCHEMBL18985314 | 0.73 | MAPT (0.56) | MAPTTP53DHODHSMN1; SMN2MEN1 | |
| SCHEMBL18985281 | 0.72 | NAMPT (0.49) | MAPTTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19003466 | 0.70 | NQO2 (0.56) | MAOBMAOAMAPTTP53HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |