Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.45 |
| ▸ | LOX | P28300 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19726966 | 0.94 | LOXL2 (0.42) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL22298873 | 0.91 | LOXL2 (0.39) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL19304419 | 0.88 | LOXL2 (0.41) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL18948475 | 0.88 | LOXL2 (0.41) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL22298880 | 0.86 | LOXL2 (0.47) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL18672470 | 0.85 | LOXL2 (0.44) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL26774132 | 0.80 | LOXL2 (0.41) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL22586037 | 0.78 | LOXL2 (0.46) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL18855226 | 0.78 | LOXL2 (0.46) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL20793984 | 0.77 | LOXL2 (0.40) | LOXL2LOXRXRAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |