Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19304419 | 1.00 | LOXL2 (0.41) | LOXL2LOXNR1I2RXRAGRIN1 | |
| SCHEMBL22298873 | 0.97 | LOXL2 (0.39) | LOXL2LOXNR1I2RXRAGRIN1 | |
| SCHEMBL19003529 | 0.88 | LOXL2 (0.45) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL20793984 | 0.87 | LOXL2 (0.40) | LOXL2LOXNR1I2RXRAGRIN1 | |
| SCHEMBL18879275 | 0.87 | LOXL2 (0.40) | LOXL2LOXNR1I2RXRAGRIN1 | |
| SCHEMBL19726966 | 0.82 | LOXL2 (0.42) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL22298880 | 0.81 | LOXL2 (0.47) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL26774132 | 0.81 | LOXL2 (0.41) | LOXL2LOXRXRAGRIN1GRIN2B | |
| SCHEMBL22260475 | 0.80 | NR1I2 (0.37) | LOXL2NR1I2SLC2A1KDM4EGPR84 | |
| SCHEMBL174988 | 0.80 | NR1I2 (0.39) | NR1I2SLC2A1KDM4EGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676780-B2 | Piperazine-substituted [1,2,4]triazolo[1,5-C]quinazolin-5-amine compounds with A2A antagonist properties | MERCK SHARP & DOHME CORP. (US) | 2017-06-13 | — | — | US | disclosed |