Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835263 | 0.92 | OPRM1 (0.34) | OPRM1OPRD1OPRK1OPRL1SLC6A2 | |
| SCHEMBL7929733 | 0.88 | NR1I2 (0.39) | NR1I2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL20371511 | 0.84 | OPRM1 (0.36) | NR1I2LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL20371549 | 0.84 | OPRM1 (0.36) | NR1I2LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL19478566 | 0.78 | NR1I2 (0.49) | NR1I2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23344676 | 0.78 | OPRM1 (0.49) | OPRM1OPRD1OPRK1OPRL1EPHX2 | |
| SCHEMBL22571302 | 0.78 | OPRM1 (0.49) | OPRM1OPRD1OPRK1OPRL1EPHX2 | |
| SCHEMBL25150664 | 0.78 | NR1I2 (0.33) | NR1I2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL18853904 | 0.78 | NR1I2 (0.42) | NR1I2LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL22169024 | 0.78 | OPRM1 (0.35) | OPRM1OPRD1OPRK1OPRL1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |