Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003530 | 0.92 | NR1I2 (0.36) | OPRM1OPRD1OPRK1OPRL1SLC6A2 | |
| SCHEMBL7929733 | 0.88 | NR1I2 (0.39) | OPRM1OPRD1OPRK1OPRL1TSHR | |
| SCHEMBL21164276 | 0.83 | TSHR (0.35) | TSHRESR1ESR2 | |
| SCHEMBL19278380 | 0.82 | MEN1 (0.34) | TSHRESR1ESR2 | |
| SCHEMBL18885342 | 0.82 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL10292091 | 0.80 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3ESR1ESR2 | |
| SCHEMBL19697820 | 0.78 | TSHR (0.32) | TSHRALDH1A1 | |
| SCHEMBL22169024 | 0.78 | OPRM1 (0.35) | OPRM1OPRD1OPRK1OPRL1TSHR | |
| SCHEMBL8735807 | 0.78 | NOS2 (0.35) | CNR2ESR1ESR2 | |
| SCHEMBL20371511 | 0.77 | OPRM1 (0.36) | OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010147975-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2010-12-23 | — | — | WO | disclosed |