Sennoside B

Sennoside B

SCHEMBL19004132

O=C(O)c1cc(O)c2c(c1)C([C@H]1c3cc(C(=O)O)cc(O)c3C(=O)c3c(O[C@@H]4OC(CO)[C@@H](O)[C@H](O)[C@H]4O)cccc31)c1cccc(OC3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c1C2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 4/20 1.00
HKDC1 Q2TB90 3/20 1.00
L3MBTL1 Q9Y468 3/20 1.00
TDP1 Q9NUW8 3/20 1.00
KDM4E B2RXH2 3/20 1.00
MAPT P10636 3/20 1.00
TNNI3 P19429 2/20 1.00
TNNT2 P45379 2/20 1.00
TNNC1 P63316 2/20 1.00
MEN1 O00255 2/20 1.00
CYP3A4 P08684 2/20 1.00
MAPK1 P28482 2/20 1.00
RECQL P46063 2/20 1.00
KMT2A Q03164 2/20 1.00
NPC1 O15118 1/20 1.00
RAB9A P51151 1/20 1.00
LMNA P02545 1/20 1.00
GLA P06280 1/20 1.00
THRB P10828 1/20 1.00
HPGD P15428 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sennoside B SCHEMBL14478776 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL15216902 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL19235654 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL17430774 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL19004127 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL23685626 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL441194 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL17131971 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside A,B SCHEMBL20822082 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL14353400 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017103931-A1 SMALL MOLECULES AGAINST CANCER BIOKINE THERAPEUTICS LTD. (IL) 2017-06-22 WO disclosed