Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 12/20 | 0.51 |
| ▸ | RXRA | P19793 | 6/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20584769 | 0.99 | IDO1 (0.51) | IDO1RXRAGRIN1GRIN2BALDH1A1 | |
| Hydrochloric Acid SCHEMBL29694899 | 0.99 | IDO1 (0.51) | IDO1RXRAGRIN1GRIN2BALDH1A1 | |
| SCHEMBL21118120 | 0.95 | IDO1 (0.51) | IDO1RXRAGRIN1GRIN2BALDH1A1 | |
| SCHEMBL21326535 | 0.91 | IDO1 (0.49) | IDO1RXRAGRIN1GRIN2BALDH1A1 | |
| SCHEMBL29099217 | 0.88 | IDO1 (0.47) | IDO1RXRAGRIN1GRIN2B | |
| SCHEMBL30628091 | 0.88 | IDO1 (0.47) | IDO1RXRAGRIN1GRIN2B | |
| SCHEMBL27414157 | 0.88 | IDO1 (0.49) | IDO1 | |
| SCHEMBL21326537 | 0.88 | IDO1 (0.40) | IDO1ALDH1A1HPGDALOX15NPSR1 | |
| SCHEMBL29099089 | 0.88 | IDO1 (0.50) | IDO1 | |
| SCHEMBL21377776 | 0.88 | IDO1 (0.48) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3389783-B1 | NOVEL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-07-03 | — | — | EP | disclosed |
| CN-110891942-B | Oxadiazole derivative, preparation method and medical application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| US-11078168-B2 | Substituted N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | Phenex Discovery Verwaltungs-GmbH (DE) | 2021-08-03 | — | — | US | disclosed |
| CN-110891942-A | Oxadiazole derivative, preparation method and medical application thereof | 四川科伦博泰生物医药股份有限公司 | 2020-03-17 | — | — | CN | disclosed |
| US-20190292160-A1 | SUBSTITUTED N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Phenex Discovery Verwaltungs-GmbH (DE) | 2019-09-26 | — | — | US | disclosed |
| EP-3535259-A1 | SUBSTITUTED N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3- DIOXYGENASE | Phenex Discovery Verwaltungs-GmbH (DE) | 2019-09-11 | — | — | EP | disclosed |
| US-20190169140-A1 | IDO1 INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2019-06-06 | — | — | US | disclosed |
| WO-2019011170-A1 | OXADIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL APPLICATION THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-01-17 | — | — | WO | disclosed |
| US-20180362482-A1 | NOVEL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-12-20 | — | — | US | disclosed |
| WO-2017106062-A1 | NOVEL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078168-B2 | Substituted N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, INMT | IDO1 1/4885RXRA 4214/4885GRIN1 383/4885 |
| US-20190169140-A1 | IDO1 INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | IDO1, IDO2, INMT | IDO1 1/4885RXRA 3119/4885GRIN1 222/4885 |
| US-20180362482-A1 | NOVEL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | IDO1, IDO2, TPH1 | IDO1 1/4885RXRA 2367/4885GRIN1 887/4885 |
| US-20190292160-A1 | SUBSTITUTED N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, INMT | IDO1 1/4885RXRA 4214/4885GRIN1 383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.