Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 4/20 | 0.58 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | AKT2 | P31751 | 9/20 | 0.57 |
| ▸ | PRKACA | P17612 | 5/20 | 0.56 |
| ▸ | PRKACG | P22612 | 5/20 | 0.56 |
| ▸ | PRKACB | P22694 | 5/20 | 0.56 |
| ▸ | AKT1 | P31749 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2938675 | 0.78 | AKT2 (0.70) | NEK2AKT2PRKACAPRKACGPRKACB | |
| SCHEMBL27628959 | 0.78 | AKT2 (0.60) | NEK2PLK1AKT2PRKACAPRKACG | |
| SCHEMBL28753405 | 0.78 | AKT2 (0.60) | NEK2PLK1AKT2PRKACAPRKACG | |
| SCHEMBL1900509 | 0.75 | NEK2 (0.38) | NEK2PLK1AKT2PRKACAPRKACG | |
| SCHEMBL19288719 | 0.72 | AKT2 (0.54) | NEK2PLK1AKT2PRKACAPRKACG | |
| SCHEMBL4920760 | 0.72 | PRMT1 (0.70) | PRKACACYP3A4MAPK14LMNALRRK2 | |
| SCHEMBL1692416 | 0.71 | PI4KA (0.52) | AKT2PRKACACYP3A4LMNADRD3 | |
| SCHEMBL30862619 | 0.70 | PI4KA (0.55) | AKT2PRKACAPRKACGPRKACBLMNA | |
| Hypoxanthine SCHEMBL10708632 | 0.69 | ALDH1A1 (0.62) | — | |
| SCHEMBL2561791 | 0.69 | JAK2 (0.64) | PRKACAMAPK14LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505766-B2 | Kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150045343-A1 | KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | disclosed |
| EP-2558099-A2 | KINASE INHIBITORS | The Regents Of The University Of California, San Francisco (US) | 2013-02-20 | — | — | EP | disclosed |
| US-20130035325-A1 | KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-02-07 | — | — | US | disclosed |
| WO-2011060440-A2 | KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035325-A1 | KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K8 | NEK2 79/4885PLK1 43/4885AKT2 110/4885 |
| US-20150045343-A1 | KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K8 | NEK2 79/4885PLK1 43/4885AKT2 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.