SCHEMBL2938675

SCHEMBL2938675

c1ccc(-c2ncnc3nc[nH]c23)cc1

nearest known ligand 0.70

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
AKT2 P31751 8/20 0.70
PRKACA P17612 4/20 0.62
PRKACG P22612 4/20 0.62
PRKACB P22694 4/20 0.62
ADORA3 P0DMS8 3/20 0.60
ADORA2A P29274 3/20 0.60
ADORA1 P30542 3/20 0.60
MAPK14 Q16539 2/20 0.59
AKT1 P31749 2/20 0.54
NEK2 P51955 1/20 0.52
CDC7 O00311 2/20 0.51
DBF4 Q9UBU7 2/20 0.51
EGFR P00533 1/20 0.51
CSF1R P07333 1/20 0.51
NT5C2 P49902 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28753405 0.81 AKT2 (0.60) AKT2PRKACAPRKACGPRKACBMAPK14
SCHEMBL27628959 0.81 AKT2 (0.60) AKT2PRKACAPRKACGPRKACBMAPK14
SCHEMBL18486287 0.80 TOP2A (0.62) AKT2PRKACAPRKACGPRKACBNEK2
SCHEMBL19288719 0.79 AKT2 (0.54) AKT2PRKACAPRKACGPRKACBAKT1
SCHEMBL1900510 0.78 NEK2 (0.58) AKT2PRKACAPRKACGPRKACBMAPK14
SCHEMBL3492637 0.77 AKT2 (0.50) AKT2PRKACAPRKACGPRKACBMAPK14
SCHEMBL30862619 0.76 PI4KA (0.55) AKT2PRKACAPRKACGPRKACB
SCHEMBL28765140 0.76 AKT2 (0.52) AKT2PRKACAPRKACGPRKACBMAPK14
SCHEMBL7035594 0.76 PI4KA (0.50) AKT2PRKACAPRKACGPRKACBCDC7
SCHEMBL24500180 0.75 ADORA3 (1.00) ADORA3ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4363043-B1 COMPOSITIONS FOR USE IN METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS NOVOCURE GMBH (CH) 2026-04-22 EP claimed
CN-118931997-A Method for synthesizing adenosine and/or uridine by three-enzyme cascade catalysis 上海飞腾医药科技有限公司 2024-11-12 CN claimed
US-20240316012-A1 METHODS FOR TREATING LYMPHOMA NORTHWESTERN UNIVERSITY (US) 2024-09-26 US claimed
US-20240219403-A1 METHODS FOR INHIBITING KRAS ONCOPROTEIN THROUGH ENHANCED GTPASE ACTIVITY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-07-04 US claimed
WO-2022217073-A1 METHODS FOR INHIBITING KRAS ONCOPROTEIN THROUGH ENHANCED GTPASE ACTIVITY MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2022-10-13 WO claimed
WO-2022093770-A1 COMBINATION THERAPY WITH PI3K-AKT-MTOR INHIBITORS AND FERROPTOSIS INDUCING AGENTS TO TREAT CANCER MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2022-05-05 WO claimed
CN-102293119-A Processing method for increasing benefits of banana ears 2011-12-28 CN claimed
US-5817799-A 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-10-06 US claimed
EP-0540686-B1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES US COMMERCE (US) 1995-08-30 EP claimed
EP-0540686-A4 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES US COMMERCE (US) 1993-05-26 EP claimed
EP-0540686-A1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES. US COMMERCE (US) 1993-05-12 EP claimed
WO-1992001700-A1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) 1992-02-06 WO claimed
CN-121991068-A 6-Phenyl-purine derivative, preparation method and medical application thereof 南通大学 2026-05-08 CN disclosed
CN-121991068-A 6-Phenyl-purine derivative, preparation method and medical application thereof 南通大学 2026-05-08 CN disclosed
EP-4729067-A2 ELECTRODE ASSEMBLY FOR APPLYING TUMOR TREATING FIELDS WITH A SHEET OF ANISOTROPIC MATERIAL Novocure GmbH (CH) 2026-04-22 EP disclosed
US-12415844-B2 BCMA specific VCAR compositions and methods for use POSEIDA THERAPEUTICS, INC. (US) 2025-09-16 US disclosed
WO-2000069876-A1 4'-C-ETHYNYL PYRIMIDINE NUCLEOSIDES YAMASA CORPORATION (JP) 2000-11-23 WO disclosed
WO-2000069877-A1 4'-C-ETHYNYL PURINE NUCLEOSIDES YAMASA CORPORATION (JP) 2000-11-23 WO disclosed
US-6103707-A TREATMENT OF HERPES SIMPLEX VIRUS 1 (HSV-1), HERPES SIMPLEX VIRUS 2 (HSV-2), HUMAN CYTOMEGALOVIRUS (HCMV) AND VARICELLA-ZOSTER VIRUS YAMASA CORPORATION (JP) 2000-08-15 US disclosed
EP-0839813-A1 9-(2-DEOXY-2-FLUORO-4-THIO-BETA-D-ARABINOFURANOSYL)PURINE DERIVATIVES YAMASA CORPORATION (JP) 1998-05-06 EP disclosed