Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183072 | 0.91 | NR1H2 (0.47) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL31569288 | 0.90 | NR1H2 (0.46) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL17790245 | 0.84 | P2RX7 (0.48) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL13575643 | 0.83 | NR1H2 (0.47) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL601417 | 0.83 | P2RX7 (0.47) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL31568967 | 0.83 | P2RX7 (0.47) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL10007648 | 0.83 | P2RX7 (0.51) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL28887447 | 0.82 | NR1H2 (0.49) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL17788667 | 0.81 | NR1H2 (0.45) | NR1H2PDK2MAPTPOLBCKS1B | |
| SCHEMBL10235383 | 0.81 | NR1H2 (0.45) | NR1H2PDK2MAPTPOLBCKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207504-B | Phthalazinone derivatives, preparation method and use thereof | 四川科伦博泰生物医药股份有限公司 | 2020-03-10 | — | — | CN | disclosed |
| WO-2017101796-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-06-22 | — | — | WO | disclosed |