Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 2/20 | 0.68 |
| ▸ | ALB | P02768 | 1/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.68 |
| ▸ | SHH | Q15465 | 1/20 | 0.68 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.68 |
| ▸ | SMO | Q99835 | 1/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.68 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018130 | 0.85 | SMO (0.71) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL10029762 | 0.84 | ALB (0.74) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL27707312 | 0.84 | USP28 (0.64) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1020284 | 0.83 | ALB (0.69) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL27688103 | 0.83 | USP28 (0.66) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1018176 | 0.83 | USP28 (0.68) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1018656 | 0.83 | ALB (0.68) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL30572237 | 0.83 | USP28 (0.68) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL30572250 | 0.83 | ALB (0.68) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1017891 | 0.82 | USP28 (0.70) | USP28ALBHTR1ASLC6A2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321261-A1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | Curis, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |
| US-9687498-B1 | Composition for preventing or treating muscle wasting-related disease and use thereof | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2017-06-27 | — | — | US | disclosed |
| US-20170173064-A1 | COMPOSITION FOR PREVENTING OR TREATING MUSCLE WASTING-RELATED DISEASE AND USE THEREOF | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2017-06-22 | — | — | US | disclosed |