Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 3/20 | 0.66 |
| ▸ | ALB | P02768 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.66 |
| ▸ | DRD3 | P35462 | 1/20 | 0.66 |
| ▸ | HTR2B | P41595 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | SHH | Q15465 | 1/20 | 0.66 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.66 |
| ▸ | SMO | Q99835 | 1/20 | 0.66 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27688080 | 0.89 | USP28 (0.62) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL27688156 | 0.88 | ALB (0.55) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1016564 | 0.86 | USP28 (0.72) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL19005840 | 0.83 | USP28 (0.68) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL10029762 | 0.83 | ALB (0.74) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL30572092 | 0.83 | USP28 (0.67) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL2121442 | 0.83 | USP28 (0.67) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL26034506 | 0.83 | USP28 (0.62) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL30572222 | 0.82 | USP28 (0.66) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1020512 | 0.82 | USP28 (0.66) | USP28ALBHTR1ASLC6A2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102964294-A | Pyridyl inhibitors of hedgehog signalling | GENENTECH INC | 2013-03-13 | — | — | CN | disclosed |
| CN-101072755-A | Pyridyl inhibitors of Hedgehog signaling | GENENTECH INC (US) | 2007-11-14 | — | — | CN | disclosed |