Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.43 |
| ▸ | FURIN | P09958 | 1/20 | 0.42 |
| ▸ | MASP2 | O00187 | 3/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 4/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900645 | 1.00 | KLKB1 (0.43) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL3154110 | 0.89 | KLKB1 (0.42) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL1432471 | 0.89 | KLKB1 (0.42) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL3157804 | 0.88 | MASP2 (0.44) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL3157823 | 0.88 | MASP2 (0.44) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL3141397 | 0.88 | KLKB1 (0.43) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL3141379 | 0.88 | KLKB1 (0.43) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL1432594 | 0.87 | FURIN (0.45) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL3149464 | 0.87 | FURIN (0.45) | KLKB1FURINMASP2F7KLK1 | |
| SCHEMBL1906175 | 0.86 | PSMB1 (0.43) | KLKB1FURINMASP2HTRA1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |