Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.81 |
| ▸ | KDR | P35968 | 7/20 | 0.77 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.77 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.77 |
| ▸ | FLT4 | P35916 | 2/20 | 0.70 |
| ▸ | SRC | P12931 | 2/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.70 |
| ▸ | STK17B | O94768 | 1/20 | 0.70 |
| ▸ | STK10 | O94804 | 1/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12012 | 0.90 | EGFR (1.00) | EGFRKDREPHB4EPHA2FLT4 | |
| SCHEMBL17520338 | 0.90 | EGFR (1.00) | EGFRKDREPHB4EPHA2FLT4 | |
| SCHEMBL11395 | 0.89 | EGFR (1.00) | EGFRKDREPHB4EPHA2FLT4 | |
| SCHEMBL907931 | 0.87 | KDR (1.00) | EGFRKDREPHB4EPHA2ERBB2 | |
| SCHEMBL17520333 | 0.87 | EGFR (0.95) | EGFRKDREPHB4EPHA2FLT4 | |
| SCHEMBL906652 | 0.86 | KDR (1.00) | EGFRKDREPHB4EPHA2ERBB2 | |
| SCHEMBL11132 | 0.85 | EGFR (1.00) | EGFRKDREPHB4EPHA2FLT4 | |
| SCHEMBL17520332 | 0.85 | EGFR (1.00) | EGFRKDREPHB4EPHA2FLT4 | |
| SCHEMBL8669 | 0.84 | EGFR (1.00) | EGFRKDREPHB4EPHA2FLT4 | |
| SCHEMBL22962474 | 0.84 | EGFR (0.85) | EGFRKDREPHB4FLT4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181554-A1 | QUINAZOLINE DERIVATIVE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2017-06-21 | — | — | EP | disclosed |