Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 8/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RPA1 | P27694 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897820 | 0.81 | MALT1 (0.69) | MALT1MEN1KMT2ANFKB1NFKB2 | |
| SCHEMBL1897746 | 0.80 | MALT1 (0.77) | MALT1MEN1KMT2ANFKB1NFKB2 | |
| SCHEMBL1514681 | 0.76 | L3MBTL1 (0.89) | MALT1MEN1KMT2ASMPD1L3MBTL1 | |
| SCHEMBL9643919 | 0.76 | MALT1 (0.73) | MALT1MEN1KMT2ANFKB1NFKB2 | |
| SCHEMBL1899635 | 0.75 | MALT1 (0.69) | MALT1MEN1KMT2ANFKB1NFKB2 | |
| SCHEMBL2531978 | 0.73 | RPA1 (0.65) | MALT1MEN1KMT2ANFKB1NFKB2 | |
| SCHEMBL11105052 | 0.72 | FLT3 (0.78) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6107458 | 0.72 | DHODH (0.60) | MALT1MEN1KMT2ACNR2CNR1 | |
| SCHEMBL4500796 | 0.71 | L3MBTL1 (1.00) | MALT1MEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL9891582 | 0.71 | CNR2 (0.81) | KMT2ACNR2CNR1CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |