Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 8/20 | 0.77 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | RPA1 | P27694 | 2/20 | 0.65 |
| ▸ | DHODH | Q02127 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897820 | 0.89 | MALT1 (0.69) | MALT1MAPK9MEN1KMT2ASMPD1 | |
| SCHEMBL1899635 | 0.89 | MALT1 (0.69) | MALT1MAPK9MEN1KMT2ASMPD1 | |
| SCHEMBL6340248 | 0.88 | MAPK9 (0.92) | MALT1MAPK9MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1514681 | 0.85 | L3MBTL1 (0.89) | MALT1MEN1KMT2ASMPD1L3MBTL1 | |
| SCHEMBL7746824 | 0.84 | MALT1 (0.59) | MALT1MAPK9MEN1KMT2ASMPD1 | |
| SCHEMBL9643919 | 0.82 | MALT1 (0.73) | MALT1MEN1KMT2ASMPD1NFKB1 | |
| SCHEMBL12530816 | 0.81 | MCHR1 (0.62) | MALT1MAPK9MEN1KMT2ANFKB1 | |
| SCHEMBL1900691 | 0.80 | MALT1 (0.66) | MALT1MAPK9MEN1KMT2ASMPD1 | |
| SCHEMBL4500796 | 0.80 | L3MBTL1 (1.00) | MALT1MEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL6342046 | 0.79 | PTGS2 (0.87) | MAPK9SMN1; SMN2PTGS1EPHX2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |
| US-7790761-B2 | Blockade of voltage dependent sodium channels | UNIVERSITY COLLEGE LONDON (GB) | 2010-09-07 | — | — | US | disclosed |
| US-20060100248-A1 | Blockade of voltage dependent sodium channels | GARTHWAITE GITI | 2006-05-11 | — | — | US | disclosed |
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100248-A1 | Blockade of voltage dependent sodium channels | CACNA1I, CACNA1F, CACNA1C | MALT1 3269/4885MAPK9 1136/4885MEN1 1208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.