Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19618140 | 0.83 | ALDH1A1 (0.44) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 | |
| SCHEMBL4734623 | 0.83 | ALDH1A1 (0.50) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 | |
| SCHEMBL12774529 | 0.78 | KDM4C (0.42) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 | |
| SCHEMBL22219838 | 0.78 | ALDH1A1 (0.44) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 | |
| SCHEMBL20312833 | 0.78 | HDAC4 (0.42) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 | |
| SCHEMBL17083356 | 0.77 | KDM4E (0.43) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 | |
| SCHEMBL10169213 | 0.77 | ALDH1A1 (0.48) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 | |
| SCHEMBL22087923 | 0.77 | KDM4E (0.43) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 | |
| SCHEMBL15275549 | 0.77 | ACHE (0.46) | ALDH1A1TP53MAPTCYP3A4HPGD | |
| SCHEMBL10227137 | 0.77 | ALDH1A1 (0.47) | KDM4EALDH1A1HDAC4HDAC8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208000-B2 | Eis inhibitors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-02-19 | — | — | US | disclosed |
| US-20170174639-A1 | EIS INHIBITORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174639-A1 | EIS INHIBITORS | ABCC1, ATP5ME, ABCG2 | KDM4E 3294/4885ALDH1A1 819/4885HDAC4 1207/4885 |
| US-10208000-B2 | Eis inhibitors | ABCC1, ATP5ME, ABCG2 | KDM4E 3294/4885ALDH1A1 819/4885HDAC4 1207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.