Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898043 | 0.86 | ELANE (0.43) | TLR8TLR7ELANEMEN1KMT2A | |
| SCHEMBL1896698 | 0.84 | ELANE (0.38) | TLR8TLR7ADORA2AELANEMEN1 | |
| SCHEMBL1901663 | 0.83 | TLR8 (0.44) | TLR8TLR7ADORA3ADORA2AMEN1 | |
| SCHEMBL1900995 | 0.82 | HSP90AB1 (0.43) | TLR8TLR7ADORA3ADORA2AELANE | |
| SCHEMBL1898389 | 0.81 | TLR7 (0.52) | TLR8TLR7ADORA3ADORA2AMEN1 | |
| SCHEMBL5194004 | 0.75 | TLR8 (0.58) | TLR8TLR7ADORA3ADORA2AELANE | |
| SCHEMBL1778208 | 0.75 | TLR7 (0.51) | TLR8TLR7ADORA3ADORA2AMEN1 | |
| SCHEMBL1897131 | 0.74 | SLC6A4 (0.37) | TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL1897931 | 0.73 | SLC6A4 (0.39) | TLR8TLR7 | |
| SCHEMBL1898044 | 0.73 | TLR8 (0.42) | TLR8TLR7ADORA3ADORA2AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943610-B2 | Pyrazolopyridine-1,4-diamines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2011-05-17 | — | — | US | disclosed |