Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.58 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3991826 | 0.93 | TLR8 (0.70) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3991913 | 0.90 | TLR7 (0.51) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3992188 | 0.89 | TLR8 (0.51) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3993609 | 0.86 | TLR8 (0.57) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL5507105 | 0.85 | TLR8 (0.41) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL5192462 | 0.85 | TLR8 (0.41) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL5571999 | 0.83 | TLR8 (0.54) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3995270 | 0.83 | TLR8 (0.60) | TLR8TLR7 | |
| SCHEMBL3999203 | 0.82 | ADORA3 (0.54) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL3995835 | 0.82 | TLR8 (0.53) | TLR8TLR7ADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863814-A1 | 1-SUBSTITUTED PYRAZOLO (3,4-C) RING COMPOUNDS AS MODULATORS OF CYTOKINE BIOSYNTHESIS FOR THE TREATMENT OF VIRAL INFECTIONS AND NEOPLASTIC DISEASES | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107851-A1 | 1-SUBSTITUTED PYRAZOLO (3,4-C) RING COMPOUNDS AS MODULATORS OF CYTOKINE BIOSYNTHESIS FOR THE TREATMENT OF VIRAL INFECTIONS AND NEOPLASTIC DISEASES | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |