Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898044 | 0.86 | TLR8 (0.42) | TLR8ESR1ATMMEN1KMT2A | |
| SCHEMBL1896699 | 0.84 | CASR (0.37) | TLR8ESR1KDM4EPOLBMAPT | |
| SCHEMBL1901666 | 0.83 | ADORA2A (0.41) | TLR8TLR7ADORA2AADORA3ADORA1 | |
| SCHEMBL1900994 | 0.82 | TLR8 (0.39) | TLR8ESR1ATMMEN1KMT2A | |
| SCHEMBL1898389 | 0.81 | TLR7 (0.52) | TLR8MEN1KMT2APOLBMAPT | |
| SCHEMBL1897133 | 0.74 | SLC6A4 (0.43) | TLR7 | |
| Hydrochloric Acid SCHEMBL1897933 | 0.73 | SLC6A4 (0.45) | TLR8TLR7 | |
| SCHEMBL1898043 | 0.73 | ELANE (0.43) | TLR8MEN1KMT2APOLBMAPT | |
| SCHEMBL1778208 | 0.72 | TLR7 (0.51) | TLR8MEN1KMT2AMAPTTLR7 | |
| SCHEMBL1894211 | 0.71 | TLR7 (0.41) | HSP90AB1TLR8ESR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943610-B2 | Pyrazolopyridine-1,4-diamines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2011-05-17 | — | — | US | disclosed |