SCHEMBL19010959

SCHEMBL19010959

CC1(C)c2cc(-c3ccccc3)ccc2-c2ccc(N(c3ccc(-c4ccc5oc6ccccc6c5c4)cc3)c3cccc4c3-c3ccccc3C43c4ccccc4-c4ccccc43)cc21

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 2/20 0.33
PLA2G2A P14555 2/20 0.32
PLA2G4A P47712 2/20 0.32
HSP90AA1 P07900 1/20 0.31
HSP90AB1 P08238 1/20 0.31
PLA2G10 O15496 1/20 0.31
PDK2 Q15119 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16544690 0.96 ALK (0.33) ALKHSP90AA1HSP90AB1
SCHEMBL20345992 0.96 ALK (0.33) ALKPLA2G2APLA2G4A
SCHEMBL20345974 0.96 ALK (0.33) ALKPLA2G2APLA2G4A
SCHEMBL19001767 0.95 PLA2G2A (0.33) PLA2G2APLA2G4AHSP90AA1HSP90AB1PLA2G10
SCHEMBL25121475 0.94 MMP12 (0.31) ALKPDK2
SCHEMBL24647475 0.94 ALK (0.33) ALKHSP90AA1HSP90AB1
SCHEMBL20345961 0.93 ALK (0.33) ALKHSP90AA1HSP90AB1
SCHEMBL25145846 0.93 HSP90AA1 (0.32) ALKHSP90AA1HSP90AB1
SCHEMBL24974893 0.93
SCHEMBL19883102 0.93

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017102064-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2017-06-22 WO disclosed