Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 3/20 | 0.45 |
| ▸ | CPB1 | P15086 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901151 | 1.00 | MASP2 (0.45) | MASP2CPB1EPHX1METAP2METAP1 | |
| Trifluoroacetic Acid SCHEMBL1432457 | 0.93 | MASP2 (0.43) | MASP2CPB1EPHX1METAP2METAP1 | |
| SCHEMBL3154833 | 0.83 | MASP2 (0.48) | MASP2CPB1METAP2METAP1GABRP | |
| SCHEMBL4310703 | 0.83 | MASP2 (0.43) | MASP2CPB1EPHX1GABRPGABRD | |
| SCHEMBL1432393 | 0.82 | MASP2 (0.43) | MASP2CPB1EPHX1NAMPTCPB2 | |
| SCHEMBL1432406 | 0.82 | MASP2 (0.43) | MASP2CPB1EPHX1NAMPTCPB2 | |
| SCHEMBL1432085 | 0.82 | MASP2 (0.44) | MASP2CPB2PPIB | |
| SCHEMBL3157818 | 0.81 | MASP2 (0.43) | MASP2CPB1EPHX1METAP2METAP1 | |
| SCHEMBL1433675 | 0.81 | MASP2 (0.43) | MASP2CPB1EPHX1METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL1907358 | 0.81 | METAP2 (0.41) | MASP2EPHX1METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102076666-A | Aminopyridine derivatives | VANTIA LTD | 2011-05-25 | — | — | CN | disclosed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |