Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.50 |
| ▸ | PRKACA | P17612 | 4/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15235359 | 0.85 | ALDH1A1 (0.45) | RPS6KA5PRKACARPS6KB1GSK3BROCK1 | |
| SCHEMBL6945320 | 0.85 | MAPT (0.41) | RPS6KA5PRKACARPS6KB1GSK3BROCK1 | |
| SCHEMBL14390002 | 0.83 | RPS6KA5 (0.53) | RPS6KA5HTTALDH1A1TSHRKDM4E | |
| SCHEMBL14364662 | 0.81 | ALDH1A1 (0.42) | RPS6KA5PRKACARPS6KB1GSK3BROCK1 | |
| SCHEMBL1901563 | 0.81 | ALDH1A1 (0.43) | RPS6KA5PRKACARPS6KB1GSK3BROCK1 | |
| SCHEMBL1898102 | 0.81 | RPS6KB1 (0.70) | RPS6KA5PRKACARPS6KB1GSK3BROCK1 | |
| SCHEMBL6945316 | 0.79 | GAA (0.42) | GSK3BALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL1898594 | 0.79 | KDM4E (0.46) | HTTALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL3979773 | 0.77 | HPGD (0.62) | RPS6KA5PRKACARPS6KB1GSK3BROCK1 | |
| SCHEMBL12676401 | 0.77 | ALDH1A1 (0.46) | HTTALDH1A1TSHRKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322521-A1 | Heteroaryl compounds useful as inhibitors of GSK-3 | Vertex Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-2322521-A1 | Heteroaryl compounds useful as inhibitors of GSK-3 | Vertex Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| US-20070270420-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF GSK-3 | VERTEX PHARMACEUTICALS INCORPORATED | 2007-11-22 | — | — | US | disclosed |
| US-20070270420-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF GSK-3 | VERTEX PHARMACEUTICALS INCORPORATED | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270420-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF GSK-3 | GSK3B, GSK3A, GSKIP | RPS6KA5 387/4885PRKACA 197/4885RPS6KB1 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.