Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | PRKACA | P17612 | 3/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12676401 | 0.86 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1901248 | 0.85 | RPS6KA5 (0.50) | MAPTALDH1A1PRKACARPS6KB1GSK3B | |
| SCHEMBL15235359 | 0.81 | ALDH1A1 (0.45) | ALDH1A1PRKACARPS6KB1GSK3BROCK1 | |
| SCHEMBL14390002 | 0.79 | RPS6KA5 (0.53) | MAPTALDH1A1RPS6KA5KDM4EMEN1 | |
| SCHEMBL14364662 | 0.77 | ALDH1A1 (0.42) | MAPTALDH1A1PRKACARPS6KB1GSK3B | |
| SCHEMBL1901563 | 0.77 | ALDH1A1 (0.43) | MAPTALDH1A1PRKACARPS6KB1GSK3B | |
| SCHEMBL6945316 | 0.75 | GAA (0.42) | MAPTALDH1A1GSK3BKDM4EMEN1 | |
| SCHEMBL1898594 | 0.75 | KDM4E (0.46) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1898102 | 0.74 | RPS6KB1 (0.70) | MAPTALDH1A1PRKACARPS6KB1GSK3B | |
| SCHEMBL14364664 | 0.70 | ALDH1A1 (0.43) | ALDH1A1PRKACARPS6KB1GSK3BROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034037-A1 | Heteroaryl compounds useful as inhibitors of GSK-3 | VERTEX PHARMACEUTICALS, INCORPORATED | 2004-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034037-A1 | Heteroaryl compounds useful as inhibitors of GSK-3 | GSK3B, GSK3A, GSKIP | MAPT 256/4885ALDH1A1 3514/4885PRKACA 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.