Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | FURIN | P09958 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901386 | 1.00 | MCHR1 (0.46) | MCHR1KDM4EALDH1A1OPRD1KMT2A | |
| SCHEMBL1905796 | 0.91 | HTT (0.43) | MCHR1KDM4EALDH1A1OPRD1KMT2A | |
| SCHEMBL1905797 | 0.91 | HTT (0.43) | MCHR1KDM4EALDH1A1OPRD1KMT2A | |
| SCHEMBL1902805 | 0.90 | OPRD1 (0.46) | MCHR1OPRD1PIN1LCKPSMB8 | |
| SCHEMBL1902802 | 0.90 | OPRD1 (0.46) | MCHR1OPRD1PIN1LCKPSMB8 | |
| SCHEMBL1906667 | 0.89 | MCHR1 (0.44) | MCHR1ALDH1A1OPRD1KMT2AMEN1 | |
| SCHEMBL1901459 | 0.89 | OPRD1 (0.45) | MCHR1OPRD1LCKPSMB8PSMB5 | |
| SCHEMBL1906669 | 0.89 | MCHR1 (0.44) | MCHR1ALDH1A1OPRD1KMT2AMEN1 | |
| SCHEMBL1904628 | 0.88 | MCHR1 (0.50) | MCHR1OPRD1LCKPSMB5FURIN | |
| SCHEMBL1906797 | 0.88 | OPRD1 (0.47) | MCHR1OPRD1LCKPSMB8PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |