Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | FURIN | P09958 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902802 | 1.00 | OPRD1 (0.46) | OPRD1MCHR1LCKFURINCTSS | |
| SCHEMBL1901386 | 0.90 | MCHR1 (0.46) | OPRD1MCHR1LCKFURINCTSS | |
| SCHEMBL1906667 | 0.90 | MCHR1 (0.44) | OPRD1MCHR1LCKFURINCTSS | |
| SCHEMBL1906669 | 0.90 | MCHR1 (0.44) | OPRD1MCHR1LCKFURINCTSS | |
| SCHEMBL1901384 | 0.90 | MCHR1 (0.46) | OPRD1MCHR1LCKFURINCTSS | |
| SCHEMBL1901459 | 0.90 | OPRD1 (0.45) | OPRD1MCHR1LCKFURINCTSS | |
| SCHEMBL1906797 | 0.89 | OPRD1 (0.47) | OPRD1MCHR1LCKCTSSCTSK | |
| SCHEMBL1906792 | 0.89 | OPRD1 (0.47) | OPRD1MCHR1LCKCTSSCTSK | |
| SCHEMBL1904628 | 0.87 | MCHR1 (0.50) | OPRD1MCHR1LCKFURINCTSS | |
| SCHEMBL1904838 | 0.87 | TACR1 (0.44) | OPRD1MCHR1LCKFURINCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |