Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.36 |
| ▸ | JAK1 | P23458 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SPR | P35270 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19014464 | 0.87 | JAK2 (0.30) | JAK2JAK1 | |
| SCHEMBL20682368 | 0.84 | ATM (0.37) | JAK2JAK1 | |
| SCHEMBL19014320 | 0.83 | JAK2 (0.31) | JAK2JAK1SPR | |
| SCHEMBL19013661 | 0.81 | GLRA1 (0.35) | JAK2JAK1 | |
| SCHEMBL19014043 | 0.77 | JAK2 (0.37) | JAK2JAK1SMN1; SMN2 | |
| SCHEMBL19014178 | 0.77 | JAK2 (0.36) | JAK2JAK1 | |
| SCHEMBL19013834 | 0.76 | JAK2 (0.39) | JAK2JAK1 | |
| SCHEMBL19013716 | 0.75 | JAK2 (0.35) | JAK2JAK1 | |
| SCHEMBL19013856 | 0.75 | JAK2 (0.35) | JAK2JAK1 | |
| SCHEMBL10196653 | 0.74 | HSD11B1 (0.33) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103188-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-22 | — | — | WO | disclosed |