Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.36 |
| ▸ | JAK1 | P23458 | 6/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20682197 | 0.86 | JAK2 (0.33) | JAK2JAK1CNR1 | |
| SCHEMBL19014087 | 0.85 | JAK2 (0.33) | JAK2JAK1 | |
| SCHEMBL20682336 | 0.84 | JAK2 (0.36) | JAK2JAK1 | |
| SCHEMBL13265396 | 0.80 | MAPT (0.43) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL19013704 | 0.79 | JAK2 (0.37) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19014064 | 0.77 | JAK2 (0.36) | JAK2JAK1 | |
| SCHEMBL19013652 | 0.75 | JAK2 (0.37) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL25074013 | 0.75 | ALDH1A1 (0.41) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL19014312 | 0.75 | JAK2 (0.45) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL10196653 | 0.74 | HSD11B1 (0.33) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103188-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-22 | — | — | WO | disclosed |