Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19014058 | 0.90 | EPHX2 (0.32) | CCR2JAK2JAK1 | |
| SCHEMBL20682206 | 0.81 | CCR2 (0.34) | CCR2JAK2JAK1 | |
| SCHEMBL14211363 | 0.79 | CCR2 (0.32) | CCR2 | |
| SCHEMBL19013670 | 0.77 | EPHX2 (0.34) | CCR2 | |
| SCHEMBL19014535 | 0.74 | CCR2 (0.43) | CCR2JAK2JAK1 | |
| SCHEMBL19014504 | 0.73 | JAK1 (0.37) | CCR2JAK2JAK1 | |
| SCHEMBL19014086 | 0.73 | NPC1 (0.34) | CCR2JAK1 | |
| SCHEMBL19014405 | 0.73 | NPC1 (0.32) | CCR2 | |
| SCHEMBL20682199 | 0.71 | ATM (0.33) | CCR2JAK2JAK1 | |
| SCHEMBL19013820 | 0.71 | JAK2 (0.39) | CCR2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103188-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-22 | — | — | WO | disclosed |