Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20682349 | 0.82 | SPR (0.37) | SPRJAK2JAK1SMN1; SMN2VNN1 | |
| SCHEMBL19014176 | 0.81 | SPR (0.36) | SPRJAK2JAK1SMN1; SMN2VNN1 | |
| SCHEMBL19014507 | 0.78 | SPR (0.39) | SPRJAK2JAK1SMN1; SMN2VNN1 | |
| SCHEMBL27897406 | 0.77 | SPR (0.48) | SPRSMN1; SMN2VNN1CRHBPCRHR2 | |
| SCHEMBL19014064 | 0.73 | JAK2 (0.36) | SPRJAK2JAK1SMN1; SMN2 | |
| SCHEMBL19014554 | 0.72 | POLB (0.47) | SPRSMN1; SMN2VNN1CRHBPCRHR2 | |
| SCHEMBL20682368 | 0.71 | ATM (0.37) | JAK2JAK1RXFP1 | |
| SCHEMBL4550272 | 0.70 | SPR (0.46) | SPRSMN1; SMN2VNN1RXFP1DPP8 | |
| SCHEMBL19014320 | 0.70 | JAK2 (0.31) | SPRJAK2JAK1 | |
| SCHEMBL18390508 | 0.70 | CYP2D6 (0.44) | SPRJAK2JAK1SMN1; SMN2DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103188-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-22 | — | — | WO | disclosed |