Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19013769 | 0.89 | L3MBTL1 (0.43) | L3MBTL1GAAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19013774 | 0.85 | HSD17B10 (0.44) | L3MBTL1GAAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19013777 | 0.84 | ALDH1A1 (0.40) | L3MBTL1GAAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19013779 | 0.82 | POLB (0.42) | L3MBTL1GAAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19013776 | 0.82 | ALDH1A1 (0.41) | L3MBTL1GAAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19014029 | 0.81 | ALDH1A1 (0.38) | L3MBTL1GAAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19013778 | 0.81 | POLB (0.44) | L3MBTL1GAAALDH1A1MAPK1KMT2A | |
| SCHEMBL19013770 | 0.81 | ALDH1A1 (0.38) | L3MBTL1GAAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL19012270 | 0.80 | AAK1 (0.42) | GAAHSD17B10ALDH1A1KMT2ATSHR | |
| SCHEMBL20592269 | 0.80 | AAK1 (0.42) | GAAHSD17B10ALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106352-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-06-22 | — | — | WO | disclosed |