Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.37 |
| ▸ | LATS1 | O95835 | 5/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13757948 | 0.78 | KMT2A (0.39) | MAPK1 | |
| SCHEMBL17135791 | 0.72 | AKT2 (0.41) | MAPK8ROCK2AURKAAURKBINCENP | |
| SCHEMBL2556871 | 0.72 | AKT2 (0.41) | MAPK8ROCK2AURKAAURKBINCENP | |
| SCHEMBL25693365 | 0.72 | MAPK8 (0.48) | MAPK8ROCK2LATS1AURKAAURKB | |
| SCHEMBL3819229 | 0.71 | GAA (0.43) | — | |
| SCHEMBL3419294 | 0.68 | AKT2 (0.52) | MAPK8ROCK2AURKAAURKBINCENP | |
| SCHEMBL1474718 | 0.68 | NUDT1 (0.38) | MKNK1MKNK2 | |
| SCHEMBL19678811 | 0.68 | NUDT1 (0.38) | GRM4 | |
| SCHEMBL19679368 | 0.66 | NUDT1 (0.62) | AURKAGRM4ROCK1 | |
| SCHEMBL22550724 | 0.66 | NUDT1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181564-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | Genentech, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |