Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 2/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8506192 | 0.96 | HTT (0.63) | HTTSMN1; SMN2LMNANPC1TSHR | |
| SCHEMBL1904097 | 0.91 | HTT (0.70) | HTTSMN1; SMN2LMNANPC1TSHR | |
| SCHEMBL11500313 | 0.81 | SMN1; SMN2 (0.56) | HTTSMN1; SMN2LMNANPC1TSHR | |
| SCHEMBL9607949 | 0.79 | HTT (0.55) | HTTSMN1; SMN2LMNANPC1TSHR | |
| SCHEMBL13948948 | 0.78 | LMNA (0.81) | HTTSMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL8505732 | 0.77 | HTT (0.63) | HTTSMN1; SMN2LMNANPC1TSHR | |
| SCHEMBL10914077 | 0.77 | RAB9A (0.63) | HTTSMN1; SMN2LMNANPC1TSHR | |
| SCHEMBL3966396 | 0.77 | HTT (0.68) | HTTSMN1; SMN2LMNANPC1TSHR | |
| SCHEMBL8505626 | 0.77 | HTT (0.68) | HTTSMN1; SMN2LMNANPC1TSHR | |
| SCHEMBL8516166 | 0.77 | HTT (0.77) | HTTSMN1; SMN2LMNANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320904-A2 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010030757-A2 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS INC. (US) | 2010-03-18 | — | — | WO | disclosed |