Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Melatonin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A known ✓ | P48039 | 13/20 | 1.00 |
| ▸ | MTNR1B known ✓ | P49286 | 10/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | NOTUM | Q6P988 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | CYP1A1 | P04798 | 1/20 | 1.00 |
| ▸ | MPO | P05164 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | NQO2 | P16083 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melatonin SCHEMBL8060688 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL29349848 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL4686085 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL28743439 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL28602603 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL28994307 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL3845735 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL8850894 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL29153193 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL28400730 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 69307 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146967-A1 | DEVICE AND SENSOR FOR DETECTION OF AN ANALYTE | REMINDED, INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4401569-B1 | BULK MELT-TO-MAKE PECTIN-BASED GUMMY MIX PRECURSOR AND METHODS OF MAKING AND USING | M2M GUMMIES LLC (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4747627-A1 | METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS | Matterworks Inc (US) | 2026-05-27 | — | — | EP | claimed |
| US-12636271-B2 | Combination comprising N-acetyl-L-cysteine and its use | IASOMAI AB (SE) | 2026-05-26 | — | — | US | claimed |
| CN-122081254-A | Method for promoting escherichia coli to synthesize serotonin and melatonin and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122074651-A | Chitosan-chlamydomonas reinhardtii protein composite carrier and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122095084-A | Antigen-specific T cell receptors and chimeric antigen receptors and methods of use in modulation of immune signaling for cancer immunotherapy | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075404-A | Liquid formulations and methods for inhibiting pentetic acid degradation | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075484-A | Application of melatonin in bilirubin encephalopathy anti-inflammatory intervention | — | 2026-05-26 | — | — | CN | claimed |
| CN-122084892-A | Stable antibody conjugate for radioimmunoassay kit and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| EP-0035856-B1 | PHARMACEUTICAL AND DIETARY COMPOSITIONS | EFAMOL LIMITED (GB) | 1984-07-04 | — | — | EP | claimed |
| EP-0019423-B1 | PHARMACEUTICAL AND DIETARY COMPOSITION COMPRISING GAMMA-LINOLENIC ACIDS | EFAMOL LIMITED (GB) | 1984-06-13 | — | — | EP | claimed |
| EP-0004770-B1 | PHARMACEUTICAL AND DIETARY COMPOSITION COMPRISING GAMMA-LINOLENIC ACIDS | EFAMOL LIMITED (GB) | 1984-06-13 | — | — | EP | claimed |
| EP-0078434-A1 | Pharmaceutical and dietary compositions | EFAMOL LIMITED (GB) | 1983-05-11 | — | — | EP | claimed |
| EP-0071357-A1 | Pharmaceutical and dietary composition when used for enhancement of 1-series PG production | EFAMOL LIMITED (GB) | 1983-02-09 | — | — | EP | claimed |
| US-4309415-A | LINOLENIC ACID OR DERIVATIVE WITH MATERIAL WHICH ENHANCES BIOSYNTHESIS OF THROMBOXANE A2 | VERRONMAY LIMITED (GB) | 1982-01-05 | — | — | US | claimed |
| EP-0037175-A1 | Pharmaceutical compositions | EFAMOL LIMITED (GB) | 1981-10-07 | — | — | EP | claimed |
| EP-0035856-A2 | Pharmaceutical and dietary compositions | EFAMOL LIMITED (GB) | 1981-09-16 | — | — | EP | claimed |
| EP-0019423-A1 | Pharmaceutical and dietary composition comprising gamma-linolenic acids | EFAMOL LIMITED (GB) | 1980-11-26 | — | — | EP | claimed |
| EP-0004770-A2 | Pharmaceutical and dietary composition comprising gamma-linolenic acids | EFAMOL LIMITED (GB) | 1979-10-17 | — | — | EP | claimed |