Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Melatonin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A known ✓ | P48039 | 13/20 | 1.00 |
| ▸ | MTNR1B known ✓ | P49286 | 10/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | NOTUM | Q6P988 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | CYP1A1 | P04798 | 1/20 | 1.00 |
| ▸ | MPO | P05164 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | NQO2 | P16083 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melatonin SCHEMBL8060688 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL29349848 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL19018 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL28743439 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL28602603 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL28994307 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL3845735 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL8850894 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL29153193 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| Melatonin SCHEMBL28400730 | 0.99 | MTNR1A (0.97) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1935227-A | Medicine composition for improving sleep | SSP CO LTD (JP) | 2007-03-28 | — | — | CN | claimed |
| WO-2024058984-A2 | METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES | MarvelBiome, Inc. (US) | 2024-03-21 | — | — | WO | disclosed |
| CN-117210388-A | Goat and sheep intestine organoid culture medium and application thereof | 内蒙古大学 | 2023-12-12 | — | — | CN | disclosed |
| EP-3621462-A1 | COMPOSITION FOR ENHANCED ABSORPTION OF SUPPLEMENTS | The Liv Group Inc. (US) | 2020-03-18 | — | — | EP | disclosed |
| WO-2018209327-A1 | COMPOSITION FOR ENHANCED ABSORPTION OF SUPPLEMENTS | The LIV Group Inc. (US) | 2018-11-15 | — | — | WO | disclosed |
| EP-3377896-A1 | HIGH-THROUGHPUT IMAGING-BASED METHODS FOR PREDICTING CELL-TYPE-SPECIFIC TOXICITY OF XENOBIOTICS WITH DIVERSE CHEMICAL STRUCTURES | Agency For Science, Technology And Research (SG) | 2018-09-26 | — | — | EP | disclosed |
| WO-2018118197-A1 | HEALTHIER AGING IN DOMESTICATED ANIMALS | POSTREL RICHARD (US) | 2018-06-28 | — | — | WO | disclosed |
| CN-108065241-A | Lactagogue chicken stewes mushroom | 倪世昌 | 2018-05-25 | — | — | CN | disclosed |
| EP-3258910-A1 | TOPICAL LIQUID COMPOSITION COMPRISING MELATONIN | Ares Trading S.A. (CH) | 2017-12-27 | — | — | EP | disclosed |
| WO-2017091147-A1 | HIGH-THROUGHPUT IMAGING-BASED METHODS FOR PREDICTING CELL-TYPE-SPECIFIC TOXICITY OF XENOBIOTICS WITH DIVERSE CHEMICAL STRUCTURES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-06-01 | — | — | WO | disclosed |
| EP-1199304-A1 | Bicyclic compounds and pharmaceutical composition containing tricyclic compound for treating or preventing sleep disorders | Takeda Chemical Industries, Ltd. (JP) | 2002-04-24 | — | — | EP | disclosed |
| US-6218429-B1 | TREATING MELATONIN RELATED DISORDERS (E.G. CIRCARDIAN RHYTHMS, SLEEP-AWAKE CYCLES, TIME ZONE CHANGES, SLEEP DISORDERS) | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| US-6207190-B1 | SYNERGISTIC MIXTURE TO REDUCE OCULAR PRESSURE AND IMPROVE VASCULAR HEALTH COMPRISING FOLIC ACID, A MAGNESIUM SALT, ALPHA-TOCOPHEROL, ASCORBATE AND ALPHA-LIPOIC ACID | CHRONORX, LLC | 2001-03-27 | — | — | US | disclosed |
| US-6034239-A | BINDIG TO MELATONIN RECEPTORS; SLEEP DISORDERS; GLANDULAR DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-03-07 | — | — | US | disclosed |
| EP-0885210-A1 | Tricylic compounds having binding affinity for melatonin receptors, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032871-A1 | TRICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-12 | — | — | WO | disclosed |
| WO-1995003043-A1 | SUSTAINED RELEASE ORAL COMPOSITIONS CONTAINING MELATONIN | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1995-02-02 | — | — | WO | disclosed |
| US-5196435-A | Melatonin derivatives and combinations with antiestrogen compounds for treating mammalian breast carcinoma | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| US-5023270-A | 5-Methoxypsoralen administered at bedtime | GOUPIL JEAN JACQUES (FR) | 1991-06-11 | — | — | US | disclosed |
| EP-0305194-A2 | Veterinary composition | SCHERING AGROCHEMICALS LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |