Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | PIR | O00625 | 1/20 | 0.32 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22681857 | 0.78 | KDM4C (0.41) | KCNH2CD274ALK | |
| SCHEMBL22681561 | 0.74 | CD274 (0.47) | KCNH2CD274PDCD1 | |
| SCHEMBL22681650 | 0.73 | PRKAB2 (0.43) | KCNH2ALK | |
| SCHEMBL22681887 | 0.72 | BACE1 (0.51) | KCNH2ALK | |
| SCHEMBL15839864 | 0.72 | NPC1 (0.40) | KCNH2NOTUMALK | |
| SCHEMBL22681889 | 0.71 | CD274 (0.42) | KCNH2CD274PDCD1 | |
| SCHEMBL17378737 | 0.70 | CTNNB1 (0.45) | KCNH2ALK | |
| SCHEMBL22681770 | 0.70 | KCNH2 (0.48) | KCNH2NOTUM | |
| SCHEMBL15839863 | 0.69 | TAAR1 (0.42) | KCNH2 | |
| SCHEMBL3644639 | 0.69 | FABP6 (0.41) | KCNH2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106634-A1 | N-PHENYL-PYRIDINE-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION MODULATORS | INCYTE CORPORATION (US) | 2017-06-22 | — | — | WO | disclosed |