Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19022015 | 0.90 | KEAP1 (0.41) | KEAP1NFE2L2BCHEALDH1A1MAPK1 | |
| SCHEMBL26343670 | 0.87 | KEAP1 (0.46) | KEAP1NFE2L2ALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL19022017 | 0.84 | KMT2A (0.38) | KEAP1NFE2L2BCHESMN1; SMN2KMT2A | |
| SCHEMBL19010255 | 0.83 | SMN1; SMN2 (0.41) | KEAP1NFE2L2BCHESIGMAR1SMN1; SMN2 | |
| SCHEMBL18502529 | 0.81 | POLB (0.46) | KEAP1NFE2L2SIGMAR1SMN1; SMN2GFER | |
| SCHEMBL20673395 | 0.81 | SMN1; SMN2 (0.40) | KEAP1NFE2L2ALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL10274873 | 0.81 | KEAP1 (0.48) | KEAP1NFE2L2BCHESIGMAR1KMT2A | |
| SCHEMBL19000034 | 0.80 | SMN1; SMN2 (0.42) | KEAP1NFE2L2SIGMAR1SMN1; SMN2GFER | |
| SCHEMBL10170261 | 0.80 | HPGD (0.53) | KEAP1NFE2L2SMN1; SMN2KMT2AHPGD | |
| SCHEMBL2607208 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2GFERCHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106607-A1 | POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS | MERCK PATENT GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |