Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19022015 | 0.87 | KEAP1 (0.41) | KMT2AKEAP1NFE2L2BCHE | |
| SCHEMBL20670332 | 0.85 | MCL1 (0.40) | KMT2AMCL1KEAP1NFE2L2MEN1 | |
| SCHEMBL19022011 | 0.84 | KEAP1 (0.42) | KMT2AKEAP1NFE2L2SMN1; SMN2BCHE | |
| SCHEMBL10274873 | 0.81 | KEAP1 (0.48) | KMT2AKEAP1NFE2L2BCHE | |
| SCHEMBL20785375 | 0.79 | SMN1; SMN2 (0.35) | KMT2AMCL1FAAHSMN1; SMN2ALOX15 | |
| SCHEMBL19009037 | 0.79 | ALDH1A1 (0.34) | KMT2AMCL1KEAP1NFE2L2GAA | |
| SCHEMBL12252175 | 0.79 | — | — | |
| SCHEMBL19022022 | 0.78 | KMT2A (0.33) | KMT2AMCL1FAAHSMN1; SMN2ALOX15 | |
| SCHEMBL24261162 | 0.78 | BCHE (0.51) | FAAHBCHE | |
| SCHEMBL18502528 | 0.78 | POLB (0.41) | KMT2AKEAP1NFE2L2MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106607-A1 | POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS | MERCK PATENT GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |