Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | XIAP | P98170 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905042 | 1.00 | MEN1 (0.39) | MEN1KMT2AXIAPALDH1A1LMNA | |
| SCHEMBL1904624 | 1.00 | MEN1 (0.39) | MEN1KMT2AXIAPALDH1A1LMNA | |
| SCHEMBL1907208 | 0.98 | MEN1 (0.38) | MEN1KMT2AXIAPALDH1A1LMNA | |
| SCHEMBL1902540 | 0.98 | MEN1 (0.38) | MEN1KMT2AXIAPALDH1A1LMNA | |
| SCHEMBL1903784 | 0.92 | MEN1 (0.47) | MEN1KMT2AALDH1A1POLBTACR1 | |
| SCHEMBL1907660 | 0.92 | MEN1 (0.47) | MEN1KMT2AALDH1A1POLBTACR1 | |
| SCHEMBL1905007 | 0.90 | MEN1 (0.40) | MEN1KMT2AXIAPALDH1A1LMNA | |
| SCHEMBL1906321 | 0.90 | KMT2A (0.41) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL1905746 | 0.90 | MEN1 (0.40) | MEN1KMT2AXIAPALDH1A1LMNA | |
| SCHEMBL1908228 | 0.90 | KMT2A (0.41) | MEN1KMT2AALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051673-A1 | AMINOTHIAZOLE DERIVATIVES USEFUL AS KLK1 INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051673-A1 | AMINOTHIAZOLE DERIVATIVES USEFUL AS KLK1 INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011051673-A1 | AMINOTHIAZOLE DERIVATIVES USEFUL AS KLK1 INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |