Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | SDCBP | O00560 | 1/20 | 0.39 |
| ▸ | SDC2 | P34741 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | CTSC | P53634 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | PRF1 | P14222 | 3/20 | 0.36 |
| ▸ | UGCG | Q16739 | 2/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19028085 | 0.84 | GRM5 (0.42) | METAP2PARP1MKNK1MKNK2CRBN | |
| SCHEMBL21903245 | 0.75 | MAP3K5 (0.47) | METAP2MKNK1MKNK2GABRA1MAP3K5 | |
| SCHEMBL19028112 | 0.75 | ADAM17 (0.44) | SDCBPSDC2PRF1DDB1CRBN | |
| SCHEMBL21903297 | 0.72 | MAP3K5 (0.47) | METAP2MKNK1MKNK2MAP3K5PRF1 | |
| SCHEMBL19028105 | 0.72 | GRM5 (0.42) | METAP2MAP3K5GRM4 | |
| SCHEMBL21903292 | 0.71 | MAP3K5 (0.44) | METAP2MKNK1MKNK2MAP3K5PRF1 | |
| SCHEMBL21903308 | 0.71 | MAP3K5 (0.44) | METAP2MKNK1MKNK2MAP3K5PRF1 | |
| SCHEMBL21903250 | 0.70 | MAP3K5 (0.44) | METAP2MKNK1MKNK2MAP3K5PRF1 | |
| SCHEMBL15408022 | 0.70 | LCK (0.58) | MKNK1MKNK2 | |
| SCHEMBL15847761 | 0.70 | SYK (0.48) | PARP1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017107089-A1 | 3- (1H-PYRAZOL-4-YL) PYRIDINEALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2017-06-29 | — | — | WO | claimed |