Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 8/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19028105 | 0.86 | GRM5 (0.42) | GRM5GRM1METAP2 | |
| SCHEMBL19028087 | 0.84 | METAP2 (0.41) | PARP1METAP2MKNK1MKNK2CRBN | |
| SCHEMBL20046512 | 0.72 | KDM5A (0.35) | GRM5GRM1 | |
| SCHEMBL15407177 | 0.70 | MKNK1 (0.50) | MKNK1MKNK2 | |
| SCHEMBL19028084 | 0.70 | GRM4 (0.51) | GRM1 | |
| SCHEMBL952625 | 0.69 | MAP3K5 (0.43) | — | |
| SCHEMBL19022946 | 0.69 | CRBN (0.60) | ESR2MAOAMAPK1CRBN | |
| SCHEMBL15847761 | 0.68 | SYK (0.48) | PARP1PARP2MKNK1MKNK2 | |
| SCHEMBL20132843 | 0.68 | BTK (0.40) | PARP1POLBHTTESR2PARP2 | |
| SCHEMBL18216849 | 0.68 | MTR (0.59) | MAPK1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017107089-A1 | 3- (1H-PYRAZOL-4-YL) PYRIDINEALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2017-06-29 | — | — | WO | claimed |