⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3319778 | 0.68 | — | — | |
| SCHEMBL207437 | 0.68 | — | — | |
| SCHEMBL10878614 | 0.68 | — | — | |
| SCHEMBL31563804 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL31564118 | 0.62 | — | — | |
| SCHEMBL3630049 | 0.60 | ALDH1A1 (0.30) | — | |
| SCHEMBL6234127 | 0.56 | — | — | |
| SCHEMBL6993877 | 0.53 | — | — | |
| SCHEMBL511838 | 0.52 | — | — | |
| SCHEMBL31511771 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1258533-C | Antihistaminic spiro compounds | JANSSEN PHARMACEUTICA NV (BE) | 2006-06-07 | — | — | CN | claimed |
| EP-4380941-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS FOR USE AS HER2 INHIBITORS | Bristol-Myers Squibb Company (US) | 2024-06-12 | — | — | EP | disclosed |
| WO-2023015240-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS FOR USE AS HER2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-02-09 | — | — | WO | disclosed |
| CN-106852144-B | 5,6- dihydro -4H- benzo [b] thieno-[2,3-d] azepine * derivative | 普尔莫赛德有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-106852144-B | 5,6- dihydro -4H- benzo [b] thieno-[2,3-d] azepine * derivative | 普尔莫赛德有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-106852144-B | 5,6- dihydro -4H- benzo [b] thieno-[2,3-d] azepine * derivative | 普尔莫赛德有限公司 | 2019-08-30 | — | — | CN | disclosed |
| EP-3204388-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | Pulmocide Limited (GB) | 2017-08-16 | — | — | EP | disclosed |
| CN-106852144-A | 5,6 new dihydro 4H benzo [b] thieno [2,3 d] azepine * derivatives | 普尔莫赛德有限公司 | 2017-06-13 | — | — | CN | disclosed |
| WO-2016055792-A1 | NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES | PULMOCIDE LIMITED (GB) | 2016-04-14 | — | — | WO | disclosed |
| CN-103214414-B | The diamine derivative of opticity and manufacture method thereof | SANKYO CO. (JP) | 2016-02-17 | — | — | CN | disclosed |
| CN-1745071-A | Novel ethylenediamine derivative | DAIICHI SEIYAKU CO (JP) | 2006-03-08 | — | — | CN | disclosed |
| EP-1303521-B1 | TETRAHYDRO-HETEROCYCLOAZEPINYL PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2005-02-02 | — | — | EP | disclosed |
| EP-1074549-B1 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | HOFFMANN LA ROCHE (CH) | 2003-11-19 | — | — | EP | disclosed |
| US-20020045635-A1 | Novel mGluR antagonists and a method for their synthesis | HOFFMANN-LA ROCHE, INC. | 2002-04-18 | — | — | US | disclosed |
| US-6369222-B1 | NITRO- AND CYANO-1,2,4,5-TETRAHYDRO-HETEROCYCLOAZEPINYL PYRIMIDINE DERIVATIVES; BRAIN, EYE, MUSCULAR, PSYCHOLOGICAL AND NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2002-04-09 | — | — | US | disclosed |
| US-6218385-B1 | FOR THERAPY OR PROPHYLAXIS OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS SUCH AS EPILEPSY, STROKE, CHRONIC AND ACUTE PAIN, PSYCHOSIS, SCHIZOPHRENIA, ALZHEIMER'S DISEASE, COGNITIVE DISORDERS AND MEMORY DEFICITS | HOFFMANN-LA ROCHE INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1074549-A2 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-07 | — | — | EP | disclosed |
| EP-0324610-B1 | Thieno[2,3-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LTD (GB) | 1994-04-13 | — | — | EP | disclosed |
| EP-0324610-A3 | Thieno[2,3-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1991-03-13 | — | — | EP | disclosed |
| EP-0324610-A2 | Thieno[2,3-d]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1989-07-19 | — | — | EP | disclosed |