Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293154 | 0.98 | PARP1 (0.40) | PARP1SMN1; SMN2ALOX15ALDH1A1KDM4E | |
| SCHEMBL290716 | 0.69 | OR51E2 (0.38) | PARP1ALDH1A1KDM4EKMT2ACCR8 | |
| SCHEMBL30667285 | 0.69 | DYRK1A (0.39) | PARP1ALDH1A1KDM4EKMT2ACCR8 | |
| SCHEMBL31747859 | 0.67 | CCR8 (0.32) | PARP1KMT2ACCR8 | |
| SCHEMBL13511 | 0.66 | — | — | |
| SCHEMBL29966643 | 0.64 | PARP1 (0.53) | PARP1SMN1; SMN2ALOX15ALDH1A1KDM4E | |
| SCHEMBL29420758 | 0.64 | TRIM24 (0.37) | PARP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL31468005 | 0.64 | TSHR (0.38) | ALOX15ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL20846254 | 0.64 | TSHR (0.38) | ALOX15ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL4065666 | 0.64 | TSHR (0.38) | ALOX15ALDH1A1KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11964944-B2 | Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases | THE UNIVERSITY OF CHICAGO (US) | 2024-04-23 | — | — | US | disclosed |
| US-20230140413-A1 | Compounds and Methods for Treating, Detecting, and Identifying Compounds to Treat Apicomplexan Parasitic Diseases | THE UNIVERSITY OF CHICAGO | 2023-05-04 | — | — | US | disclosed |
| US-11414385-B2 | Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases | THE UNIVERSITY OF CHICAGO | 2022-08-16 | — | — | US | disclosed |
| US-20200283391-A1 | Compounds and Methods for Treating, Detecting, and Identifying Compounds to Treat Apicomplexan Parasitic Diseases | THE UNIVERSITY OF CHICAGO | 2020-09-10 | — | — | US | disclosed |
| EP-3394032-A1 | COMPOUNDS AND METHODS FOR TREATING, DETECTING, AND IDENTIFYING COMPOUNDS TO TREAT APICOMPLEXAN PARASITIC DISEASES | The University of Chicago (US) | 2018-10-31 | — | — | EP | disclosed |
| WO-2017112678-A1 | COMPOUNDS AND METHODS FOR TREATING, DETECTING, AND IDENTIFYING COMPOUNDS TO TREAT APICOMPLEXAN PARASITIC DISEASES | MCLEOD RIMA (US) | 2017-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283391-A1 | Compounds and Methods for Treating, Detecting, and Identifying Compounds to Treat Apicomplexan Parasitic Diseases | TUBB1, MYADM, TUBB | PARP1 3880/4885SMN1; SMN2 4842/4885ALOX15 2858/4885 |
| US-11964944-B2 | Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases | TUBB1, MYADM, TUBB | PARP1 4108/4885SMN1; SMN2 4839/4885ALOX15 2609/4885 |
| US-20230140413-A1 | Compounds and Methods for Treating, Detecting, and Identifying Compounds to Treat Apicomplexan Parasitic Diseases | TUBB1, MYADM, TUBB | PARP1 4108/4885SMN1; SMN2 4839/4885ALOX15 2609/4885 |
| US-11414385-B2 | Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases | TUBB1, MYADM, TUBB | PARP1 3880/4885SMN1; SMN2 4842/4885ALOX15 2858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.