Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | RAB9A | P51151 | 2/20 | 0.77 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RRM1 | P23921 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2608307 | 0.88 | NPC1 (1.00) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL11743247 | 0.88 | NPC1 (1.00) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL7793321 | 0.77 | NPC1 (0.77) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL7793323 | 0.77 | NPC1 (0.77) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL7793264 | 0.77 | NPC1 (0.68) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL7793269 | 0.77 | NPC1 (0.68) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL10942218 | 0.76 | NPC1 (0.74) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL22995747 | 0.74 | NPC1 (0.71) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL22198250 | 0.74 | NPC1 (0.71) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B | |
| SCHEMBL22198249 | 0.74 | SMN1; SMN2 (0.71) | NPC1SMN1; SMN2RAB9AGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |