Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11374923 | 0.87 | ADORA2B (0.62) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL19036507 | 0.85 | ADORA2B (0.68) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL11380544 | 0.84 | ADORA2B (0.59) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL13659055 | 0.84 | SMN1; SMN2 (0.66) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| Dimethylamine SCHEMBL11381767 | 0.83 | SMN1; SMN2 (0.59) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL8666393 | 0.83 | ADORA2B (0.79) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL11377411 | 0.82 | ADORA2B (0.59) | ADORA2BLMNAMAPTRXFP1 | |
| SCHEMBL4516866 | 0.82 | ADORA2B (1.00) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL16120984 | 0.81 | ADORA2B (0.81) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL11383083 | 0.81 | SMN1; SMN2 (0.63) | ADORA2BLMNAMAPTSMN1; SMN2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |