Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.42 |
| ▸ | CCNK | O75909 | 10/20 | 0.42 |
| ▸ | CDK9 | P50750 | 10/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 10/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.42 |
| ▸ | CDK7 | P50613 | 8/20 | 0.42 |
| ▸ | CCNH | P51946 | 8/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17150598 | 0.87 | HTR6 (0.40) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL19040162 | 0.84 | CCNT1 (0.53) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL17150714 | 0.81 | CCNK (0.53) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL17150567 | 0.78 | HTR6 (0.48) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL17150459 | 0.77 | CCNK (0.69) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL19040166 | 0.75 | CDK2 (0.43) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL19040167 | 0.74 | CDK2 (0.39) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL18069809 | 0.72 | CDK7 (0.48) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL17150641 | 0.71 | CDK2 (0.38) | CDK2CCNT1CCNKCDK9CDK12 | |
| SCHEMBL17150473 | 0.69 | CDK7 (0.51) | CDK2CCNT1CCNKCDK9CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180208578-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2018-07-26 | — | — | US | disclosed |
| US-20170183355-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2017-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180208578-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | CDK2 7/4885CCNT1 34/4885CCNK 8/4885 |
| US-20170183355-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | CDK2 7/4885CCNT1 34/4885CCNK 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.