Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21298708 | 1.00 | TSHR (0.38) | TSHRALDH1A1RAB9AADRB2ADRB1 | |
| SCHEMBL1297889 | 0.88 | TSHR (0.43) | TSHRALDH1A1RAB9AADRB2ADRB1 | |
| SCHEMBL1196604 | 0.81 | HSP90AA1 (0.39) | TSHRALDH1A1RAB9AADRB2ADRB1 | |
| SCHEMBL1297871 | 0.81 | RAB9A (0.41) | TSHRALDH1A1RAB9AADRB2ADRB1 | |
| SCHEMBL28522849 | 0.81 | RAB9A (0.41) | TSHRALDH1A1RAB9AADRB2ADRB1 | |
| SCHEMBL1169548 | 0.80 | TSHR (0.41) | TSHRALDH1A1RAB9AADRB2ADRB1 | |
| SCHEMBL6141274 | 0.79 | ADRB2 (0.45) | TSHRALDH1A1RAB9AADRB2ADRB1 | |
| SCHEMBL1196568 | 0.79 | ADRB2 (0.45) | TSHRALDH1A1RAB9AADRB2ADRB1 | |
| SCHEMBL13149938 | 0.78 | MEN1 (0.45) | ALDH1A1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL3099571 | 0.78 | MEN1 (0.45) | ALDH1A1MEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017112853-A1 | METHODS OF TREATING PULMONARY DISEASES AND DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2017-06-29 | — | — | WO | disclosed |