Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19045148 | 0.72 | IRAK4 (0.37) | IRAK4 | |
| SCHEMBL19045690 | 0.71 | IRAK4 (0.46) | IRAK4 | |
| SCHEMBL19030317 | 0.61 | MAPT (0.44) | IRAK4 | |
| SCHEMBL19046166 | 0.59 | IRAK4 (0.54) | IRAK4 | |
| SCHEMBL21326686 | 0.58 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL19045681 | 0.56 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL19045077 | 0.53 | IRAK4 (0.36) | IRAK4 | |
| SCHEMBL19045793 | 0.53 | IRAK4 (0.36) | IRAK4 | |
| SCHEMBL25070406 | 0.50 | CYP2D6 (0.37) | — | |
| SCHEMBL25070407 | 0.50 | ATAD2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |