Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 13/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17781274 | 0.85 | KDM4E (0.57) | PDE2APDE10APDE3AALDH1A1KDM4E | |
| SCHEMBL310126 | 0.83 | PDE2A (0.59) | PDE2AHSD11B1PDE10APDE3AALDH1A1 | |
| SCHEMBL19029939 | 0.83 | LMNA (0.47) | PDE2AHSD11B1ALDH1A1LMNAKDM4E | |
| SCHEMBL10071025 | 0.83 | LMNA (0.44) | PDE2APDE10APDE3AALDH1A1LMNA | |
| SCHEMBL21326698 | 0.81 | PDE2A (0.53) | PDE2AHSD11B1PDE10APDE3A | |
| SCHEMBL19029896 | 0.81 | PDE2A (0.45) | PDE2APDE10APDE3AALDH1A1LMNA | |
| SCHEMBL30579399 | 0.75 | LMNA (0.45) | PDE2AALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL19030768 | 0.75 | LMNA (0.72) | PDE2AHSD11B1ALDH1A1LMNAKDM4E | |
| SCHEMBL27185622 | 0.75 | STING1 (0.60) | PDE2AHSD11B1PDE10APDE3AKDM4E | |
| SCHEMBL15187435 | 0.74 | MARK3 (0.46) | PDE2AHSD11B1PDE10APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |